Southampton, have reportedly already jected a £20 million offer from the merseyside club with it thought that they are waiting for an increase of £5 million, which Liverpool are now prepared to offer.
The south coast club have identified African defender Bruno Ecuele Manga as the ideal replacement, after accepting the fact that Lovren wants his desired move to Anfield.
Manga, is already a transfer target for Liverpool neighbours Everton, who have been keeping a close eye on him for some time, after his impressive displays for FC Lorient last season, however they are yet to make any kind of bid.
The 25-year-old Gabon international - who replaced Laurent Koscielny when he moved to Arsenal three years ago - played a vital role in FC Lorient's eighth place finish in Ligue 1.
Southampton are ready step up their interest in Manga, as they have now resided in the inevitable conclusion of Lovren leaving, with the player already revealing his intentions.
He has expressed his anger and frustration, in Saints rejecting an initial offer of £20 million and stating that he was not for sale. The Croat says that he was not informed of this and that he has already set his sights on the joining the Reds.
"Liverpool sent a £20m offer and they [Southampton] paid £9m for me, so they would've earned twice the amount," Lovren told reporters.
"It was in the morning and by the afternoon the club had said I was not for sale. Frankly, my head is already at Liverpool."
The Southampton powers-that-be will be sick of the sight of Liverpool as they have already lured their two most influential players away from the club, with Rickie Lambert and Adam Lallana joining earlier in the summer.
Liverpool boss Brendan Rodgers has certainly exploited Saints weakness of having to sell, after Mauricio Pochettino too charge of Tottenham, and they look set to continue that trend by completing a move for their key defender.