The winners will be left with one foot in Monday’s International Challenge Cup final, where they could potentially meet local rivals Manchester United.
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Manchester City currently top Group B of the International Challenge Cup after hammering Italian giants AC Milan 5-1.
Liverpool, meanwhile, sit level on points with the Citizens thanks to a more modest 1-0 victory over Greek champions Olympiacos - Raheem Sterling scoring the only goal of the game in that one.
City face Olympiacos in their final Group B match, on Saturday, while Liverpool take on Milan in North Carolina later on the same day.
Manchester City: Caballero, Clichy, Kolarov, Boyata, Nastasic, Fernando, Navas, Zuculini, Milner, Jovetic, Dzeko
Liverpool: Jones, Kelly, Toure, Coates, Enrique, Gerrard, Henderson, Allen, Coutinho, Lambert, Sturridge
Subs: Mignolet, Ward, Johnson, Sakho, Robinson, Lucas, Can, Suso, Ibe, Coady, Sterling, Peterson
Somewhat surprisingly, Liverpool boss Brendan Rodgers opted to start with first-choice goalkeeper Simon Mignolet and rapid winger Sterling on the substitutes’ bench.
Manchester City manager Manuel Pellegrini, meanwhile, plays summer signing Willy Caballero in goal.
The former Malaga star has been brought in to provide competition for first-choice keeper Joe Hart - and a good performance against the Reds would give Pellegrini something to think about with less than a fortnight before the Community Shield against Arsenal at Wembley Stadium.