Although a preseason friendly, the two sides rarely do anything by half measures when they meet on the field, and the fixture should be an entertaining affair.
United, under new boss Louis Van Gaal, have been all-action on their tour so far, and will be looking to cap a thoroughly successful trip with a victory over their fiercest rivals this evening.
Liverpool meanwhile have quietly impressed despite the sale of Luis Suarez to Barcelona for a club record fee. The Reds have seen off Olympiakos, AC Milan and Manchester City while United defeated Inter Milan on penalties, Roma and Real Madrid.
While the International Champions Cup is hardly the most prestigious trophy, the likes of United and Liverpool never pass up an opportunity to collect a little silverware - especially considering their respective seasons last term.
United are looking to bounce back from their seventh placed Premier League finish, and the quicker they rediscover that winning habit the better. As for Liverpool, they enjoyed a bittersweet ending to an otherwise fantastic campaign when they were pipped to the title by Manchester City.
The main goal, Champions League qualification, was secured however.
Anyway, here's how the two teams line up this evening...
De Gea; Evans, Smalling, Jones; Valencia, Herrera, Fletcher, Young; Mata; Rooney (c), Hernandez
Mignolet, Kelly, Johnson, Skrtel, Sakho, Gerrard, Allen, Henderson, Coutinho, Lambert, Sterling