Louis van Gaal takes charge of Manchester United at Old Trafford for the very first time on Tuesday night, when the Red Devils' play their final pre-season friendly against Spanish giants Valencia.
The veteran Dutch coach is expected to stick with the 3-5-2 formation which served United so well on the club's tour of the United States.
The Premier League giants secured the International Champions Cup last week, beating AS Roma, Inter Milan, Real Madrid and fierce rivals Liverpool along the way.
Indeed, the team Van Gaal picks to start against Valencia on Tuesday evening is likely to be the same side that starts against Swansea City in United's opening match of the 2014/15 Premier League campaign on Saturday afternoon.
But, for any players on the fringes of the first team along with those reportedly on the Old Trafford axe list, this will be one final chance to impress Van Gaal before the season gets underway.
Watch: Man Utd 3-1 Liverpool highlights
Old Trafford debuts for Shaw and Herrera
Two players almost certain to start - or at least feature during the match - are United's only major summer signings: Luke Shaw and Ander Herrera.
Both are relishing the prospect of playing in front of 70,000+ supporters at Manchester United's home ground - and the latter told MUTV this weekend that he is desperate to begin his Old Trafford tenure with another morale-boosting victory.
"I know it's the Theatre of Dreams and I want to play there now, I can't wait, " Herrera commented. "Things went well in America but we want to do the same in front of our supporters.
"I am really looking forward to the match. I know it's a friendly but I really want to win it.
"I played against Valencia a lot during my time in Spain, they always want to keep the ball and traditionally they are an offensive team and have just won the Emirates Cup, so it will be a good challenge for us."
It also promises to be a special night for Herrera's compatriot Juan Mata, who spent four years at the Mestalla after leaving Real Madrid in 2007.
The 26-year-old Spain international is remembered fondly by the Valencia supporters after scoring 46 goals in 174 matches for Los Che before joining Chelsea in 2011.
Mata was superb in pre-season and will once again be expected to provide ammunition for both Welbeck and Rooney, who was named Player of the Tournament at the end of the International Champions Cup.
Van Gaal should also stick with the same back three - comprised of Jonny Evans, Phil Jones and Chris Smalling - while Antonio Valencia should continue in the right wing-back position.
Manchester United - Predicted XI
De Gea; Evans, Jones, Smalling; Valencia, Shaw; Fletcher, Herrera, Mata; Rooney, Welbeck
Manchester United 2 Valencia 0