Adam Gemili and James Dasaolu are set to do battle over 100 metres as the first of two Diamond League final events heads to Zurich on Thursday.
Both athletes won European Championship's gold on the same track earlier in the month - Gemili in the 200m, and Dasaolu the 100m.
They will have a big task on their hands if they want the glory again, though, as former world record-holder Asafa Powell and ex-world champion Tyson Gay are also expected to run.
In-form Commonwealth champion Kemar Bailey-Cole and American Michael Rodgers are also in the field, with Rodgers currently top of the Diamond points standings.
Perhaps the highest quality track event of the night will be the men's 800m, however, with the great David Rudisha hoping to extend his lead in the Diamond race.
The Kenyan world record-holder, 25, has started to get back to his best after an injury-hit 2013, although he will come up against a top-class field.
Against Rudisha will be his compatriot and world champion over 1500m, Asbel Kiprop, Ethiopia's world 800m champion Mohammed Aman, NIgel Amos, who beat the Olympic champion to take the Commonwealth title, and recently crowned European champion Adam Kszczot.
Other stand-out races include the women's 100m hurdles, where Queen Harrison takes a four point lead over fellow American Dawn Harper-Nelson into the meet.
In the field, the men's triple jump is one of a number of events with all still to play for. American Will Claye leads the standings on 14 points with compatriot and Olympic champion Christian Taylor just two behind.
The women's high jump will also take place, with Croatia's Blanka Vlasic, who missed the European Championships through injury, returning after a five week layoff.
Vlasic, a two-time world champion, is joint-top of the Diamond Race standings, level with Russian athlete Mariya Kuchina and two points ahead of fellow Croat, Ana Simic.