Real Salt Lake 'stopper Nick Rimando is the only Major League Soccer player to keep his place in the first United States national squad since this summer's World Cup.
With Team USA's friendly against the Czech Republic on September 3 falling in the middle of a hectic end-of-season run-in, the division's stars have been spared - except Rimando.
Battle for a starting role
Though his Royals side host title rivals FC Dallas three days later, the 35-year-old may welcome the call-up, as he now faces a battle to claim the goalkeeping jersey during veteran Tim Howard's one-year hiatus.
A European-based octet do remain from the Brazil tournament though, including Bayern Munich's Julian Green, while there is a shock inclusion for Stanford student Jordan Morris in a particularly young squad.
The 19-year-old could become the first college player to appear for the Stars and Stripes in almost 20 years, and offers another glowing example of the successes of Seattle Sounders FC's academy.
Fellow graduate DeAndre Yedlin and teammate Clint Dempsey are among the most high-profile absentees, but their attentions will be elsewhere as the Rave Green travel to Chivas USA on the same night.
Matt Besler and Graham Zusi will also be in club action, with their Sporting Kansas City outfit hosted by Jermaine Jones' New England Revolution, while Michael Bradley and Toronto FC play at the Philadelphia Union.
Full US squad:
Jozy Altidore (Sunderland), Alejandro Bedoya (Nantes), John Brooks (Hertha Berlin), Geoff Cameron (Stoke City), Timmy Chandler (Eintracht Frankfurt), Joe Corona (Club Tijuana), Cody Cropper (Southampton), Mix Diskerud (Rosenborg), Greg Garza (Club Tijuana), Julian Green (Bayern Munich), Brad Guzan (Aston Villa), Joe Gyau (Borussia Dortmund II), Emerson Hyndman (Fulham), Fabian Johnson (Borussia Monchengladbach), Alfredo Morales (Ingolstadt), Jordan Morris (Stanford), Michael Orozco (Puebla), Tim Ream (Bolton Wanderers), Nick Rimando (Real Salt Lake), Rubio Rubin (Utrecht), Brek Shea (Stoke City), Bobby Wood (1860 Munich).
Canada, on the other hand, have elected to include their own MLS internationals for a clash with Jamaica on September 9.
Five of Bradley's Reds colleagues are on the roster, along with a party of four from the Montreal Impact. One significant omission, though, is rookie Tesho Akindele, who will instead stay with Dallas where he has become a key man.
Full Canadian squad:
Kyle Bekker (Toronto FC), Patrice Bernier (Montreal Impact), Milan Borjan (unattached), Julian de Guzman (unattached), Marcel de Jong (FC Augsburg), Dwayne de Rosario (Toronto FC), David Edgar (Birmingham City), Randy Edwini-Bonsu (Stuttgarter Kickers), Jeremy Gagnon-Lapare (Montreal Impact), Marcus Haber (Crewe Alexandra), Andre Hainault (VfR Aalen), Doneil Henry (Toronto FC), Atiba Hutchinson (Besiktas), Simeon Jackson (Coventry City), Dejan Jakovic (Shimizu S-Pulse), Nik Ledgerwood (Energie Cottbus), Ashtone Morgan (Toronto FC), Issey Nakajima-Farran (Montreal Impact), Karl Ouimette (Montreal Impact), Pedro Pacheco (CD Santa Clara), Tosaint Ricketts (Hapoel Haifa), Quillan Roberts (Toronto FC), Kenny Stamatopoulos (AIK), Adam Straith (unattached).