As reported by the Daily Mail, the Gunners midfielder picked up a knock while on international duty with his native Wales on Tuesday night and now faces a battle against the clock to be fit in time to take his place in Arsene Wenger's starting XI for Saturday's match.
Despite coming up against a team in Andorra who had lost their last 44 games and are currently ranked 199th in the world by FIFA, Tuesday night's opening Euro 2016 qualifier proved to be an immensely difficult task for Ramsey and Wales.
On a frankly disgraceful 3G surface at the Estadi Nacional that got progressively worse with every pass and every tackle, the 23-year-old badly turned his ankle in second-half stoppage-time and was replaced by Wigan Athletic's Emyr Huws with two just minutes remaining of the tie remaining.
Wales boss Chris Coleman was understandably frustrated after a narrow 2-1 win that was secured by Real Madrid sensation Gareth Bale's wonderful late free-kick and also featured a number of bad, persistent challenges on key players that disrupted the flow of the game.
Coleman sounded unsure of the severity of Ramsey's injury, suggesting that the next 24-48 hours would be crucial in terms of determining the likelihood of him being available to Arsenal this weekend.
Having moved to Arsenal from Cardiff in 2008, Ramsey has already suffered his fair share of unfortunate injury trouble, with this and his initial lack of impact leading many Arsenal fans to doubt his future at the top level.
However, the 2013/14 campaign - or certainly the opening half, anyway - saw Ramsey make a real breakthrough.
Scoring 10 goals in 23 domestic outings, he was rewarded for his fine form with a new £90,000-per-week deal back in March.
Ramsey has featured in all three of Arsenal's top-flight fixtures so far this season, netting in the opening day victory over Crystal Palace and the eventful draw with Everton at Goodison Park.
While Wenger might be without Ramsey for the visit of Manchester City, striker Danny Welbeck - who switched to North London from rivals United on deadline day - is likely to make his debut for the club ahead of Yaya Sanogo.