Manchester City will be without injured duo Stevan Jovetic and Fernando when they take on Arsenal this weekend.
City boss Manuel Pellegrini confirmed the pair will both be out of the visit to north London, when speaking to his club's official website.
Midfield hard-man Fernando originally picked up a knock in his sides shock 1-0 home defeat against Stoke and then suffered a further injury in training, sidelining him for up to two weeks.
That means he may miss the crucial Champions League opener against Bayern Munich as well as Chelsea's trip to the Etihad Stadium.
Fernando has made a bright start to life in the Premier League and Pellegrini was understandably disappointed by the news, he said: "He has a problem and he could be out for two weeks - we will see but it is a blow."
Jovetic out again
Like Fernando, Jovetic has had a fine start to the season, netting twice in the 3-1 home win against Liverpool.
However, the striker's progress has been halted after he returned home early from international duty with Montenegro after picking up a slight hamstring problem.
The issue will certainly rule him out of the Arsenal fixture but Pellegrini is hopeful he'll be back in action soon: "Stevan won't play against Arsenal but I am hoping he will be OK next week."
The set-back comes at a time when the former Fiorentina man was finally fulfilling his potential in a City shirt after an injury-hit first season at the club limited his opportunities.
It wasn't all bad news for City fans, however, as Pellegrini revealed two of the club's summer signings could be set to make their first team bow.
The City manager confirmed Frank Lampard and Eliaquim Mangala will both be in the squad having sat out the first three games of the season.
The duo are now both ready for action and that means Premier League fans could see Lampard in a kit other than Chelsea's for the first time in over a decade. The England midfielder made a surprise loan move to the champions after joining their Major League Soccer franchise New York City when his Stamford Bridge contract expired.
City fans will also be excited at the prospect of seeing £32 million man Mangala in action after his protracted move from Porto was finally completed this summer.