Di Maria inspired and gave Manchester United their first victory under Louis van Gaal after scoring a left footed shot from a well-taken free kick and setting up Juan Mata for the final fourth.
After inspiring his country - Argentina - against Germany during the international break, setting up three goals and scoring Argentine fourth, Di Maria gifted the Red Devils their first victory since May.
Money buy glory
It only cost United just under £60million to find some pace and creativity upfront, something they struggled to do since Sir Alex Ferguson retired at the end of the 2012-2013 Premier League season.
Even the charismatic Van Gaal could not inspire a perfect start with the Old Trafford side, seeing them lose against League One MK Dons by four goals earlier this month with a humiliatingly poor performance.
But patience and hard work always pay off, and that must be at the heart of Van Gaal's philosophy, who still found reasons to critique his team following the 4-0 win.
Di Maria just showed his price-tag on the pitch last Sunday afternoon. Playing in midfield, it let him providing a glut of goal opportunities, linking-up well with his teammates up front.
Di Maria position
But where does Di Maria plays his best football? It seems that playing as a forward winger does fit him definitely, but it's not where he has been making the biggest waves.
The former Benfica star showed against QPR he is most effective in midfield; either centrally or on the flanks. With the Argentine playing in this position, it leaves the top of United's attack free to insert a Robin van Persie; a Wayne Rooney; or even some Spanish legs with Juan Mata, who is always looking for gaps to make a clever run.
With United's current flop defence, it is important to have in midfield a player such as Di Maria with lots of experience as an attacking player but also a player with skills defensively, something that he honed during his years at Real Madrid.
For now, Van Gaal has to cope with a weakened defensive display but with Di Maria in midfield and the possible return of Juan Mata back in the same area, as Falcao should integrate the front line and play as main striker alongside Van Persie and Rooney, United's boss will have to make further signings in January to complete a dream team.
That top team the Dutch manager is currently training and building may go on to grab a Premier League title this year as Van Gaal had to wait his fourth game in charge with Bayern Munich to win a Bundesliga game, and, surprisingly, went on to win the Bundesliga in the same year. He could, this time, surprise the Premier League with Manchester United.