Manchester City's hopes of claiming a first Champions League win of the season against Roma were handed a boost after news emerged from Italy that Daniele De Rossi could miss the clash.
The Italian midfielder suffered a calf injury as his side beat Cagliari in Serie A on Sunday, and he now faces a race against time to be fit for next week's fixture.
The injury forced the 31-year-old off in the closing stages of the game, and Roma have revealed the extent of the problem in a statement on their official website.
The statement, quoted in the Manchester Evening News, read: "Daniele De Rossi underwent tests today that revealed a first-degree lesion to his left soleus muscle. He has already begun treatment on the injury."
While no time frame has been put on the recovery period, it's thought the injury could possibly rule him out of next Tuesday's clash and his absence would be good news for Manuel Pellegrini's men.
De Rossi is one of the first names on the team sheet for Roma boss Rudi Garcia having established himself as an ever-present since making his debut for his boyhood club over a decade ago and his side will undoubtedly be weaker without him.
The key Champions League clash could have seen De Rossi finally appear at the Etihad Stadium having long been linked with the Premier League champions, as well as fierce rivals Manchester United and Jose Mourinho's Chelsea.
It was the summer of 2013 when De Rossi came closest to making the move to England, eventually opting against joining David Moyes new era at Old Trafford.
By January Manchester United were struggling under Moyes and De Rossi endeared himself to City fans by insisting he would have made a huge mistake in joining their neighbours.
Italian newspaper, Il Corriere dello Sport, quoted the Italy star as saying: "It was a good thing that I didn't go to Manchester, now I would have committed suicide!"
Champions League campaign
With De Rossi potentially out of the side, Manchester City will hope to claim their first Champions League win of the season as they look to qualify from a tricky group.
In the first game of the group stages they were denied an impressive draw by a late Jerome Boateng winner for Bayern Munich, and the visit of Roma is follow by another tough away trip, this time to CSKA Moscow.
After being humbled by Barcelona at the round of 16 last season, the club's players, staff and hierarchy are hoping this will be the year they finally make an impression on Europe's premier club competition.