For Spurs boss Mauricio Pochettino, Saturday evening's clash represents his first taste of the famous old fixture and he will be desperate to improve his side's questionable record at the home of their fiercest rivals.
Tottenham have one just one league fixture on enemy turf since Arsenal moved into their new home seven years ago, with an 85th-minute Younes Kaboul winner securing an eventful 3-2 victory for a Harry Redknapp-led squad back in November 2010.
Arsenal and Tottenham have each endured mixed starts to the 2014/15 campaign, both domestically and in European competition.
After kicking off their season with a narrow victory over Crystal Palace on August 16 - a typical Arsenal home win over supposedly inferior opposition - Arsene Wenger's men have one just twice more in all competitions since and were held to three consecutive top-flight draws prior to last weekend's convincing 3-0 victory over high-flying Aston Villa.
Tottenham, meanwhile, currently sit ninth in the Premier League but have seen their bright start to life under their highly-rated new boss fizzle out somewhat in recent weeks.
Having opened the season with wins over West Ham and Queens Park Rangers, Spurs have lost two of their last three league games including Sunday's dismal defeat at home to struggling West Brom that provoked a rather angry reaction from Pochettino.
In terms of team news for this eagerly-anticipated clash, Wenger appears confident that the defensive crisis which has engulfed his squad of late will not worsen with Per Mertesacker expected to be fit for the weekend after a knock while Kieran Gibbs should also be available to start and Mathieu Flamini could also return to contention.
Arsenal will still be without the services of Nacho Monreal, Olivier Giroud and Theo Walcott for this one, however, while summer arrival Mathieu Debuchy faces three months on the sidelines after undergoing surgery on an ankle injury sustained in the 2-2 draw with champions Manchester City.
England right-back and long-term absentee Kyle Walker aside, Pochettino has relatively few injury concerns currently affecting his large first-team squad and he was able to rest the majority of his key players for Wednesday's spirited Capital One Cup third-round triumph over Championship promotion hopefuls Nottingham Forest.
With this in mind and without further ado, here are our predicted lineups for the latest instalment of this most enthralling of derbies...
Arsenal: Szczesny; Chambers, Mertesacker, Koscielny, Gibbs; Arteta, Ramsey; Sanchez, Cazorla, Ozil; Welbeck.
Tottenham: Lloris; Dier, Chiriches, Kaboul, Rose; Dembele, Capoue; Lamela, Eriksen, Chadli; Adebayor.
Sanchez - a £35 million summer signing from Barcelona - should keep his place for Arsenal after his excellent goal against Southampton in midweek, although Wenger has been experimenting with his system of late.
We expect the rest of the side should be pretty similar to the one that claimed all three points at Villa Park - if it ain't broke, don't fix it as the old saying goes.
Tottenham's lineup is far more difficult to predict as Pochettino could feasibly make any number of changes to his team after that abject loss to the Baggies.
Youngsters Harry Kane and Ryan Mason could well be given the nod after their heroics against Forest at White Hart Lane.
Do you agree with our selections? Leave your thoughts, lineups and predictions in the comment box provided below.