American captain Tom Watson has decided to send out in-form rookies Jordan Spieth and Patrick Reed early on Sunday morning in the hope to overturn Europe's 10-6 lead.
Europe on the brink
Europe need just four points from the 12 singles match so the US side need to get off to a fast start to avoid the Ryder Cup being decided early on.
The pair have won 2.5 points from their three matches so far during Friday and Saturday's fourball and foursomes. Watson's decision to leave to duo out of Friday's foursomes session after their thrashing of Ian Poulter and Stephen Gallacher in the morning session was heavily criticised.
Spieth will do battle with Graeme McDowell while Reed faces Swede Henrik Stenson. Both McDowell and Stenson took maximum point from their fourball and foursomes matches over the first two days.
Following these two matches will be the headline clash between world number one Rory McIlroy and American Rickie Fowler. The pair have faced each other twice during the first two days of the Ryder Cup with the match being halved on both occasions.
Justin Rose, who is the highest point-scorer in either line-up after taking 3.5 points from a possible four, takes on Hunter Mahan.
Scotland's Stephen Gallacher, making his first Ryder Cup appearance, will face Phil Mickelson, who is playing in his 10th. Gallacher made his debut on Friday morning but lost heavy in the fourballs and hasn't featured since.
Other matches include major winners Martin Kaymer and Bubba Watson going head-to-head while Sergio Garcia faces Jim Furyk and Ian Poulter plays Webb Simpson.
Singles matches (Tee times BST):
11:36: Graeme McDowell v Jordan Spieth
11:48: Henrik Stenson v Patrick Reed
12:00: Rory McIlroy v Rickie Fowler
12:12: Justin Rose v Hunter Mahan
12:24: Stephen Gallacher v Phil Mickelson
12:36: Martin Kaymer v Bubba Watson
12:48: Thomas Bjorn v Matt Kuchar
13:00: Sergio Garcia v Jim Furyk
13:12: Ian Poulter v Webb Simpson
13:24: Jamie Donaldson v Keegan Bradley
13:36: Lee Westwood v Jimmy Walker
13:48: Victor Dubuisson v Zach Johnson