Arsene Wenger has confirmed that both Aaron Ramsey and Mikel Arteta will miss next week's Premier League clash against Chelsea through injury.
The Gunners were forced to substitute both Ramsey and Arteta in the first half of the north London derby on Saturday evening, adding to an already bulging list of injuries.
Wenger also confirmed that Jack Wilshere is a doubt after rolling his ankle in the 1-1 draw against Tottenham.
Wenger is already without Olivier Giroud, Mathieu Debuchy, and Nacho Monreal, but it is the midfield where the situation is becoming critical.
Ramsey suffered a nasty looking hamstring injury while Arteta picked up a calf injury respectively. While Wilshere could be fit for next week, Wenger confirmed the former pair were facing at least a week out.
He said to reporters: "I don't know how long they'll be out. I think Ramsey is a hamstring and Arteta is a calf. Wilshere [has] an ankle [problem].
"Wilshere, I don't know. The two others are out for Chelsea for sure."
Theo Walcott is also on the injury list having failed to recover from a knee injury in the expected time. He has been out since January and now word has yet to be made on his return.
Wenger says Arsenal's injury problems are becoming a real source of concern for him.
"Wilshere, if you look at the incident again, has been tackled and turned his ankle over," he said.
"Ramsey is a concern that he did his hamstring. I don't understand because he had a good rest this week, I didn't play him against Southampton [in the 2-1 League Cup defeat] on Tuesday night. It's a surprise because he's usually a resistant boy.
"Suddenly we are short because if we lost three players today, and let's not forgot that we already have two out long-term plus Walcott, that's six. [Abou] Diaby is not ready so it starts to become a worry."
Arsenal face two crucial games this week against Galatasaray in the Champions League and Chelsea in the league. Having lost their opening group game to Borussia Dortmund, another loss or even a draw could make qualifying for the second round a difficult task.
Similarly, a loss to Chelsea at Stamford Bridge, where they lost 6-0 last season, would leave them trailing the leaders by nine points, making a title challenge unrealistic.