The 2014 NFL season has not been a kind one for starting quarterbacks.
Matt Schaub lost his spot in Oakland to rookie Derek Carr before the season had even started having played the main role throughout preseason.
Chad Henne was benched as another rookie Blake Bortles was given his opportunity for Jacksonville in Week Four.
And there have been plenty of others, from Sam Bradford at the Rams and RGIII at the Redskins, who have lost out to back ups due to injury.
That's without even mentioning New York Jets fans baying for Geno Smith's blood at the weekend.
One more down
Another fell today however with the Buffalo Bills announcing that EJ Manuel would be replaced by Kyle Orton for the franchise's Week Five contest against the Detroit Lions.
"Kyle Orton is our starting QB right now. We need more overall production from that position," Bills head coach Doug Marrone explained Monday afternoon.
"We came in today, looked at the tape, and made a decision that gives us the best opportunity to win.
"This is a great opportunity for him (EJ Manuel) to sit back...And work on correcting those issues."
The change comes after Manuel endured a torrid day against the Houston Texans Sunday. Despite throwing for 225 yards and two touchdowns, the former Florida State Seminole failed to produce at key moments and ended the game with two interceptions - one of which saw JJ Watt run the ball in for a spectacular pick-six on what had been a potential game winning drive for the Bills.
His defensive line didn't help him much mind with Manuel taking 16 hits during the game.
After that game Manuel seemed despondent:
"For my confidence, it's a matter of learning, continuing to learn," Manuel said.
"Understand that you can't walk around with your tail between your legs. Be a man. It is what it is. We lost a game. We didn't play as well as we wanted to."
He will have more time than ever to contemplate exactly what has gone wrong as he watched former Dallas Cowboys back up Kyle Orton take his place.
Orton will replace the Bills' 2013 first-round pick to make his first regular-season appearance for the franchise since arriving from Dallas this season.
In total, at time with the Cowboys, Denver Broncos and Chicago Bears, the 31-year-old has 70 career starts - with a .500 record to date (35W, 35L).
The Buffalo Bills hierarchy will be hoping he can make that 36 wins this weekend with the franchise having succumb to two straight defeats after beginning the season 2-0.