According to the Daily Express, the experienced Ghana international's current contract at Stade Velodrome is due to expire at the end of the season and each of those aforementioned Premier League contenders are supposedly interested in securing his services on a free transfer next summer.
This is obviously not a scenario that would suit Marseille, of course, and it is further claimed that the Ligue 1 leaders are keen to avoid the prospect of losing Ayew for absolutely nothing and are eager to ensure that they receive at least some compensation by offloading him when the transfer window re-opens in January.
A versatile attacking outlet also capable of being deployed as a support striker, Ayew has made 13 appearances for Marseille so far this season, notching four goals in all competitions as Les Phoceens have displayed their title credentials under the explosive management of notoriously controversial but pioneering Argentine boss Marco Bielsa.
Ayew - whose younger brother Jordan left the Stade Velodrome for French rivals Lorient this summer - also represented Ghana at the 2014 World Cup, starting all three of the Black Stars' Group G games and scoring against Germany in Fortaleza and the USA in Natal.
Premier League suitors
Still only 24 and with a wealth of experience already behind him, it is certainly no great surprise to see that several teams are interested in taking advantage of Ayew's contract situation.
Manchester United can already boast a wealth of impressive attacking options of course, with the dynamic Angel di Maria having proved his considerable class since his British record transfer from Real Madrid in August.
Further attacking additions should perhaps not be of the utmost priority for Louis van Gaal in either of the next two transfer windows, particularly if the Red Devils go ahead and sign Colombian striker Radamel Falcao on a permanent basis following his season-long loan spell from Monaco.
Rather, defensive recruits should probably be at the top of the club's transfer agenda, particularly in light of the recent injury crisis at Old Trafford that has served to further decimate Van Gaal's already fragile backline.
Liverpool and Tottenham could be better suitors for Ayew, although Arsenal have been linked with the player rather frequently in the past.