Manchester City v Manchester United
Wayne Rooney will start for Manchester United against Manchester City after serving a three match suspension. His return comes at the perfect time for Louis van Gaal, who is without Colombian striker Radamel Falcao for the trip to the Etihad stadium.
Sergio Aguero is likely to play a key role for Manchester City. The Argentinian has scored nine goals in nine games so far in the Premier League, bagging four against Tottenham Hotspur.
His feud with Marcos Rojo will add to the occasion as the international teammates line up against one another for the first time since Rojo's move from Sporting Lisbon. The pair were reported to have fallen out after the World Cup.
The game won't need the rivalry between Aguero and Rojo to spice things up, however. The Manchester derby has been one of the most hotly contested rivalries since the Citizens were overtaken by Sheikh Mansour in 2008.
Manchester City have one each of the last three Premier League meetings between the two with United's last win coming at the Etihad in 2012. A late Robin van Persie winner sealed a 3-2 victory that day, but United have suffered a significant downturn in form since then.
However, a win for the Red Devils will leave them just one point behind their noisy neighbours and lift them up to fifth in the table.
Manchester City XI: Hart, Zabaleta, Kolarov, Demichelis, Kompany, Fernando, Yaya Toure, Navas, Milner, Jovetic, Aguero.
Subs: Caballero, Clichy, Sagna, Fernandinho, Boyata, Dzeko, Nasri
Manchester United XI: De Gea, Valencia, Smalling, Rojo, Shaw, Blind, Fellaini, Januzaj, Rooney, Di Maria, van Persie
Subs: Lindegaard, McNair, Carrick, Fletcher, Herrera, Mata, Wilson