Hugo Lloris will miss Tottenham's trip to Greece to play Asteras Tripolis in the Europa League Group C.
The French No.1 was sent off late on a fortnight ago when Spurs strolled to a 5-1 win over their greek opponents, and rather than Harry Kane donning the gloves it will be regular backup Michel Vorm who will make his Europa League debut for Mauricio Pochettino's side.
Lloris will be joined in North London by captain Younes Kaboul, Kyle Naughton, Aaron Lennon and Emmanuel Adebayor, who have all been rested, as well as injured duo Kyle Walker (abdomen) and Nabil Bentaleb (ankle).
Tottenham cannot afford any slip ups as it is very tight in Group C. Spurs are currently second, matching top of the table's Besiktas with five points. Asteras are a point back in third, with Partizan bottom with one point.
Spurs have often struggled on their travels in Europe's secondary competition, with largely changed teams struggling to find any fluency or purpose against apparently weaker sides.
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Pochettino will know the 5-1 scoreline last time out flattered the English side and should his side return home without anything then they will probably need to win in Turkey against Besiktas.