In the last meeting between these two sides, James Wilson got his Manchester United first-team career off to a head start with two strikes against Steve Bruce's Hull City side, but his appearances since then have been somewhat limited.
But the 18-year-old must hope that he can play the Tigers every week as a place in the starting XI looks almost certain for Wilson with the deteriorating form of Robin van Persie beginning to get the better of the Dutchman, with just three goals this season for the Red Devils.
Marcos Rojo and Radamel Falcao have both made promising returns to training at Carrington during the week, yet the duo are still doubtful for the tie at the weekend.
On the other hand, things are looking a little brighter for another of their summer signings, Ander Herrera, as the Spaniard is hoping to make his first appearance since the 5-3 butchering at Leicester City over two months ago.
As far as Hull are concerned, the weather in East Yorkshire currently reflects the Tigers' season so far in the Premier League with only eleven points from twelve games.
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Queens Park Rangers and Crystal Palace are the only teams who have bowed down to Steve Bruce's under-performing side so far, therefore a result at Old Trafford seems like a disorientating thought.
Of course, victory will be the first of a kind for Hull as the travelling side have never won at Old Trafford, so the players will be given a little more motivation to go out and steal a landmark victory as they look to improve on what is the club's worst start to a Premier League season since they were relegated in the 2009/10 season.
Bruce will be boosted by the fact that Mo Diame should return to the squad after missing the unfortunate 2-1 defeat to Spurs on Sunday with tendonitis.
But Gaston Ramirez - the architect of the Tigers' downfall in that game with a unnecessary red card - will begin his three-match suspension.
Manchester United have gone into free-winning mode in terms of their form. A morale boosting triumph at the Emirates on Saturday will certainly have Louis van Gaal's side's confidence on high ahead of the visit from the East Yorkshire based side.
The recent victory over Crystal Palace and rescuing a point at the death of the game against Chelsea have also formed a more consistent form for the Red Devils this season as they have finally entered the Champions League zone.