Spurs have put together their first decent run of form under Mauricio Pochettino, having won six of their previous seven matches, and take on a Chelsea side without top scorer Diego Costa, who is suspended for this fixture after picking up his fifth yellow card of the season against Sunderland.
Loic Remy and Didier Drogba are both in contention to replace the Brazil-born Spain international, but Chelsea boss Jose Mourinho is expected to give the nod to the former, despite speculation that both strikers will start in attack.
Remy or Drogba
Remy has only scored one goal in his five Premier League appearances for the west London outfit, while Drogba has netted one in ten - that goal coming in the 1-1 draw against Manchester United in October.
That, however, was Drogba's only Premier League start for Chelsea this season. Despite having made 10 appearances, the Blues' legend has only played 166 minutes of league football since returning to Stamford Bridge.
Drogba boasts an impressive record of scoring against Tottenham, but Mourinho should opt for the youthful Remy in a bid to give Tottenham's defence the runaround.
No new injury concerns
Barring Costa and youngster Nathan Ake, who has a hamstring injury, Chelsea have a full-strength squad to choose from.
The likes of Eden Hazard, Cesc Fabregas and Oscar will be assigned the task of providing Remy or Drogba with the chances to win this match and ensure Chelsea maintain their six-point lead at the top of the Premier League table.
Mourinho's men will be desperate to get back to winning ways following Saturday's frustrating 0-0 draw at the Stadium of Light, but tonight's fixture promises to be one of their toughest of the season so far.
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Chelsea 2-1 Tottenham
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