Manchester United will be hoping to make it five Premier League wins on the bounce when they travel to the St Mary's to take on third placed Southampton on Monday evening.
Despite a number of injury problems the Red Devils have climbed the league table in recent weeks and will now be hoping to move ahead of their rivals by securing all three points in the crunch clash.
One huge boost for Louis van Gaal is the potential return of captain Wayne Rooney. The striker, of course, missed United's last fixture after sustaining a knee injury when colliding with an advertising board in the clash with Hull City.
Rooney, then, looks set to lead the line alongside Robin van Pesie, whilst the duo of James Wilson and Radamel Falcao will be knocking on the door for a starting place.
The midfield quartet should once again see the likes of Michael Carrick, Juan Mata, Ander Herrera and Marouane Fellaini star for the club at the St Mary's. There's no doubt about it, United have looked a far more balanced side since the return of Carrick, whilst Herrera has impressed in his last couple of fixtures for the club.
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Fellaini and Mata, meanwhile, will be hoping to continue their fine form after netting in United's mid-week victory over Stoke City.
Antonio Valencia and Ashley Young may predominantly be wingers, but they look set to play at full-back, with the likes of Luke Shaw and Rafael da Silva out on the sidelines.
Chris Smalling and Marcos Rojo have started to prove their credentials at the heart of United's defence of late, so they should once again partner one another against the Saints.
And, of course, the ever reliable David de Gea will start between the sticks as he looks to continue his fantastic start to the season.
Manchester United predicted XI
David de Gea, Antonio Valencia, Chris Smalling, Marcos Rojo, Ashley Young, Marouane Fellaini, Ander Herrera, Michael Carrick, Juan Mata, Wayne Rooney, Robin van Persie
Manchester United fans: Let us know your XI for Monday's showdown with the Saints. Have your say in the comments section below!