Southampton crashed out of the Capital One Cup quarter-final after a limp display that saw Sheffield United progress at their expense.
Ronald Koeman made five changes to his side for the match, but they simply failed to get going at all during the 90 minutes and only registerd one shot on target all night.
Their misery was compounded in the 63rd minute when Marc McNulty bundled home after Fraser Forster spilled a Bob Harris free kick that was straight at him.
Didn't get going
Southampton stayed in the North following the weekend's 1-0 loss to Burnley and manager Ronald Koeman went with a strong side that welcomed Morgan Schneiderlin back into the starting eleven.
The Saints though didn't really get out of first gear all evening and their best chance of the half came after Shane Long made his way down the left and put the ball across for Sadio Mane to poke wide.
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The home side saw a looping effort end up on the roof of the net amid claims that Fraser Forster was fouled which were waved away by referee Michael Oliver.
Fraser Forster was forced to make a fine save to his right after a well delivered free kick was glanced towards the bottom corner, but the 6ft 4in stopper reacted well to palm it away.
The England international did not do so well with his next attempt which came from another free kick after Sadio Mane lost possession on the edge of his own area.
Bob Harris smashed the resultant kick low and hard but it was seemingly straight forward for Forster. However a combination of power and the apparent moisture on the ball saw it squirm out of his grasp.
Marc McNulty was the first of three Sheffield United players who followed in to tap home from a yard out to send Bramall Lane wild.
The visitor's misery was compounded late on when Florin Gardos was shown a red card for hauling down McNulty when through on goal which will equal a suspension for the Romanian.
Forster made another fine save as United hit the Saints on the counter as the Premier League side pushed forward in search of an equaliser.
Both Morgan Schneiderlin and Victor Wanyama also received yellow cards which will rule them out of Saturday's match with Everton through suspension.
Not much went right for the Saints on the night and manager Ronald Koeman will be angry at the manner of the performance and lack of fight which saw his side fluff their chance of a cup semi final to a more committed lower league outfit.
Southampton player ratings
Forster - 5
Clyne - 5
Fonte - 5
Gardos - 4
Targett - 5
Wanyama - 5
Schneiderlin - 5
Ward-Prowse - 6
Mane - 4
Bertrand - 5
Long - 5
Isgrove - 5
Alderweireld - 5
Mayuka - NA