Liverpool face another tough clash on Sunday when Arsenal travel to Anfield.
The Reds have struggled so far this season and sit just 11th in the Premier League on 21 points and have already lost more games than they did last term.
Brendan Rodgers' men were thrashed 3-0 by rivals Manchester United last weekend, putting a further dampener on the side's campaign.
However, the Merseyside club did look good in their 3-1 victory against Bournemouth in the Capital One Cup mid-week and they thrashed the Gunners 5-1 in this fixture last season.
Goalkeeper - Brad Jones
It seems that Jones has taken Simon Mignolet's place in between the sticks for the indefinite future and will likely remain in goal until the January transfer window.
The Australian hasn't done all that well in the Liverpool net since replacing his counterpart in the net when pre-mediating Wayne Rooney and Robin van Persie's goals against United and could have done better for Dan Gosling's on Wednesday night.
However, it seems that Rodgers is keen to give Mignolet the cold shoulder until the Reds can buy a new shot-stopper and Jones is the man to be the stop-gap in between.
Right-back - Glen Johnson
Liverpool will need experience to stop the powerful Arsenal attack and Johnson can provide this.
Despite his contract running out at the end of the season, the England international has been preferred at right-back this season.
Johnson has bundles of pace going forwards as well as quick feet and he looks to attack given every opportunity.
Centre-back - Kolo Toure
The Ivorian is Liverpool's best defender at the minute and should again easily remain in the starting line-up.
Toure has played against top teams throughout his career, mostly when representing the opposing side and he should be ready to deal with the threat of Sanchez and co.
Despite lacking pace, the 33-year-old makes it up by reading the play well and getting into good positions that allows him to make key tackles and interceptions.
With him in the back-line, it seems that the overall moral of the Reds' defence is much more confident as he brings composure and experience.
Centre-back - Martin Skrtel
Skrtel has been a regular at the heart of the Merseyside club's back-four this term and will likely line-up once again.
The Slovakian looks much better alongside Toure as opposed to Dejan Lovren and clearly has a better understanding.
Skrtel loves getting into battles with forwards and will get precisely that against Sanchez and will thrive going head-to-head with the Chilean.
Left-back - Alberto Moreno
The position of the left-hand side of defence has been changed on a consistent basis this season and Moreno has probably done the best.
He's been the subject of two high-profile mistakes this term and the Spaniard knows he must improve defensively.
The ex-Sevilla man didn't really know his role against the Red Devils last weekend and it saw plenty of space wide on the left which was took advantage of.
One has to imagine that now playing four at the back, this will not be an occurrence and there will be less room for exposure.
Defensive-midfield - Lucas
Given the threat of the Arsenal forward-line, Rodgers will have to offer his defence protection.
Lucas has been in good form of late and has been impressive playing in this role.
He knows his duty not to go stretching forwards and snaps at the heels of the opposition when on the attack.
The Brazilian is limited in what he does, however, he's in the team to break down attacks not score goals.
Centre-midfield - Jordan Henderson
The England international has fairly struggled this term but didn't do too badly against Bournemouth.
He intelligently set-up Raheem Sterling with a calm header inside the box. His position for that showed he has an attacking presence, not scared to break into the area and all his goals have came inside the penalty area.
Henderson has an excellent engine which puts pressure on the opposition and does so from the first into the final whistle.
Centre-back - Steven Gerarrd
The Liverpool skipper couldn't make out his role against United, but played further forward mid-week which brought the best out of him.
Gerrard thrives in this role rather than just ahead of the defence and it allows him to really dictate the game.
His passing is superb and he distributes is cleverly and his dead ball ability still very much remains.
Left-wing - Lazar Markovic
Markovic has very much hit form of late.
He was superb in his short cameo against FC Basel and put in good shifts when meeting both United and Bournemouth.
The Serb has bundles of pace which wasn't displayed earlier in the year but it seems the ex-Benfica man has settled to English football.
Rodgers has said he wants Markovic to be aggressive and this is where he thrives.
The 20-year-old took his goal extremely well against the Cherries when calmly slotting his effort into the back of the net and his cross to find Henderson that lead to Sterling's goal was exquisite.
Right-wing - Adam Lallana
Lallana was impressive in the loss against Louis van Gaal's side in the first-half and it came as a surprise when dragged off at the break.
The former Southampton man has very good feet, ability to switch the ball in-between the two which forces defenders into making fouls.
He too has excellent vision that can unlock defences and it's likely Lallana will see plenty of the ball against the Gunners as his side look for him for ideas.
Striker - Raheem Sterling
The 20-year-old has been a make-shift striker of late and hasn't done badly.
Sterling had several chances against United and should have had several goals to him name but his finishing let him down.
However, he made up for that with two strikes against Eddie Howe's outfit and was a nuisance in the South-East throughout.
The England international has plenty of pace that intimidates defenders and netted in the fixture last term which will bring confidence.