Chelsea overcame West Ham on Boxing Day with the minimum of fuss as John Terry and Diego Costa scored the goals to ensure a difficult test became a comfortable triumph for the leaders.
Defeat for West Ham and victory for Southampton allowed the latter to climb above them into the Premier League's coveted top for, and Ronald Koeman's side are the next opponents for Chelsea.
St Mary's is the venue for this encounter and Jose Mourinho would appear likely to field a relatively unchanged XI against Saints following his comments in the press conference after the festive win in their London derby.
“My players are human like all the others. The point is that every match, for us, is fundamental," he said.
“You can’t choose matches where we have more chances to win than others. If they are in good condition, they play."
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Mourinho was able to play arguably his strongest team against West Ham but may consider one change from this line-up, given the injury troubles Diego Costa has endured both with Atletico Madrid and since his move to Chelsea.
Costa has, after initial fears, proven he can play three times in a week but two games in three days may be an unnecessary risk for Chelsea's top goalscorer. Didier Drogba is available to replace the Spain international if Mourinho removes him from the line of fire.
Chelsea predicted XI to face Southampton...
Thibaut Courtois; Branislav Ivanovic, Gary Cahill, John Terry, Cesar Azpilicueta; Nemanja Matic, Cesc Fabregas; Willian, Oscar, Eden Hazard; Didier Drogba.