Arsenal could be without striker Danny Welbeck for tomorrow's clash with Southampton after he picked up a thigh problem towards the end of the Gunners' 2-1 victory over West Ham on Sunday.
Arsene Wenger's side head into the game in fine form after picking up four wins in their last five games in all competitions, and will now be hoping to secure another three points at the St Mary's on New Year's Day.
There's no doubt about it, though, the Gunners will be in for quite the test against Ronald Koeman's side, who will be hoping to stay in front of their rivals in the Premier League table.
The two sides are currently level on points at the mid-way point of the season, with the winner tomorrow set to occupy the Champions League spots ahead of the third round of the FA Cup.
And, after a crucial victory over West Ham in their last outing, it's unlikely that Wenger will make too many changes for tomorrow's showdown.
It's expected that the quartet of Kieran Gibbs, Per Mertesacker, Laurent Koscielny and Mathieu Debuchy will occupy the defensive positions in front of goalkeeper Wojciech Szczesny.
Tomas Rosicky, despite having only started one league game for the north London outfit this term, could come in for Danny Welbeck, who may have to settle for a place on the bench.
That could move Alexis Sanchez into the striker position, with Santi Cazorla starring down the middle and Alex Oxlade-Chamberlain playing down the right-hand side.
The midfield duo of Mathieu Flamini and Francis Coquelin, who impressed in the club's last outing, look set to start for the Gunners once again.
Predicted Arsenal XI
Szczesny, Gibbs, Koscielny, Mertesacker, Debuchy, Flamini, Coquelin, Rosicky, Cazorla, Oxlade-Chamberlain, Sanchez