Arsenal make the trip to the south coast looking to avoid another FA Cup fourth round upset against Brighton & Hove Albion.
Some of the Premier League's top clubs stumbled at the hands of lower-league opposition yesterday (Saturday), with Chelsea and Manchester City crashing out to Bradford and Middlesbrough respectively.
Arsene Wenger has picked a strong side in a bid to avoid such a fate falling on the Gunners, with Theo Walcott back in the starting line-up at the Amex Stadium.
Wojciech Szczesny comes back in goal with David Ospina missing out altogether, whilst Olivier Giroud leads the lines as part of a 4-2-3-1 formation. Flamini and Ramsey are the holding midfielders.
For the hosts, manager Chris Hughton has named an attack-minded side with Chris O'Grady leading the line and Sam Baldock in support. Craig Mackail-Smith is on the bench as he continues to recover from injury.
The midfield battle could well be where this game is won and lost, and Inigo Calderon will be tasked with breaking up the Gunners' play for the Seagulls.
Arsenal have named Tomas Rosicky and Mesut Ozil in the starting line-up, so Wenger will be expecting the duo to produce some creative magic to break down the struggling Championship side.
Brighton & Hove Albion
Stockdale; Bruno, Greer, Dunk, Bennett; Holla, Ince; Calderon, Forster-Caskey, Baldock; O'Grady.
SUBS: Walton, Hughes, Rea, Chicksen, Colunga, March, Mackail-Smith.
Szczesny, Chambers, Koscielny, Monreal, Gibbs, Flamini, Walcott, Ramsey, Ozil, Rosicky, Giroud.
SUBS: Martinez, Mertesacker, Bellerin, Coquelin, Cazorla, Alexis, Akpom.