Not only suffering their first away defeat since November at Swansea, Manchester United also had their best striker badly injured yesterday.
Swansea completed their "double" over Manchester United this season by beating Louis van Gaal's side 2-1 at Liberty Stadium, a repeat of the scoreline in the first leg game at Old Trafford.
It was just United's second defeat, and the first away, since November 2, when they were beaten by city rival Manchester City at Etihad. Before the visit to Wales, United's only defeat in 20 matches had come at home to Southampton.
But if United fans thought their day couldn't get much worse, they were wrong. Robin van Persie, United's best striker in Premier League this season with 10 goals, was seen leaving the stadium on crutches and with a protective boot on his right foot.
Van Persie picked up an injury when the match was coming to end and United were pushing hard in search for the equaliser. According to Van Gaal, Van Persie 'could not run anymore' in the final phase of the game.
The extent of Van Persie's injury is not yet known, however Van Gaal will be hoping that it's not too serious. His side are facing a really tough battle to claim a spot in next season's Champions League.
After losing at Swansea, United's third place spot was taken by Arsenal, who got all three points at Crystal Palace. They will be out of top four, too, if Southampton defeat Liverpool on Sunday.
If United are to progress in the FA Cup, United fans will be praying Van Persie is fit and firing against his former club Arsenal on March 9 in the quarter-finals.