Cain Velasquez and Fabricio Werdum will meet to unify the Heavyweight titles and Eddie Alvarez and Gilbert Melendez will look settle the score, when the UFC returns to Mexico in June.
The organisation announced the main event bout for the Mexico card on Monday, and it is the second time they've booked the fight for a Mexico card.
Meanwhile, the co-main event of the evening will see Melendez face Alvarez in fight that had been rumoured since their Strikeforce days.
Will Velasquez make it to Mexico?
The big question on the lips of fight fans will be whether or not Velasquez can make it to the event, or if he'll be injured once more.
The reigning champ hasn't fought since October 2013 and because of that, the UFC had to make Werdum's fight with Mark Hunt an Interim title clash at UFC 180 last year - which was also in Mexico.
It was a huge blue for the UFC as Velasquez's Mexican heritage makes him the perfect star they're looking for to crack into the country which is dominated by boxing and football.
It also shone negatively on their heavyweight division and the durability of their stars.
The fight will mark the third time that the UFC Heavyweight title has had to be unified in it's history - more than any other belt in the UFC ever.
A lightweight dream match
There's less likely to be any concerns for the Alvarez-Melendez fight, which has been in the works for years.
Both are former lightweight champions in Bellator and Strikeforce and had been in negotiations to fight each other, with Melendez at one point looking to join Bellator just for the fight.
However, the UFC enacted a clause in Melendez's contract and he went on to face, and lose to, UFC Lightweight champion Anthony Pettis.
Now though, the two are finally set to lock horns and while both are at least two wins away from a potential title shot, this fight should deliver in bundles.
The card is still to be rounded out even further and there are several Mexican fighters and Latin American fighters looking for a fight so stay tuned for more UFC 188 updates.