With Liverpool going through the physical exertion of extra-time and the heartache of defeat on penalties away to Besiktas this weekend could be the perfect time for Manchester City to make the trip to Anfield.
City's record at Anfield is pretty dyer with the Citizens only recording 13 wins in 81 attempts and only one of those coming in the Premier League era, that being a 2-1 victory in May of 2003 thanks to two goals from Nicolas Anelka.
Despite defeat to Barcelona earlier in the week, Manchester City will go into the game full of confidence thanks to a second half display which showed they can match the Catalan club. Sergio Aguero's goal keeps them firmly in the tie.
Recent displays in the Premier League and the return of influential midfielder Yaya Toure fuels the belief that they can get a much-needed win to reduce Chelsea's lead to two points at the top of the table.
Last season Liverpool famously came out on top in a very close and exciting tie, which seemed put them in the driving seat for the title. However, a late slip up allowed City to overtake their rivals and claim a second Premier League crown in three years.
Despite Liverpool not being in the title race this term, the memory of last season as they let the title slip through their fingers to the Manchester club will be strong motivation.
The fact that two former Citizens lead the line for the Anfield club these days, who surely must feel they have a point to prove to their former employers should, also provide an edge and make it a very interesting encounter.
The question is simple: will Liverpool be able to bounce back physically and mentally from their Europa League defeat? But, equally, will Manchester City be able to take advantage and record only their second win at Anfield in the Premier League?