It will be a repeat of last year's memorable final during this season's Champions League quarter-final as the fierce Madrid rivals go head to head at the Vicente Calderon. Although "Los Blancos" emerged victorious from last year's epic final, they have failed to beat their bitter rivals in six attempts since that epic final in Lisbon.
The most recent of these Madrid derbies resulting in a resounding Atleti victory 4-0 as Los Blancos were well beaten at the Calderon.
So, although Atleti will be seeking to avenge their extra-time loss to Real Madrid in last year's final, they can definitely take heart from their impressive performances against their city rivals this season.
Although the attacking trio of Real Madrid, dubbed "BBC" by the press, has been faltering of late, Los Blancos are a power-house in European football and remain a threat in Europe's elite competition. Therefore, the two-leg affair promises to be a tight one to call.
Paris St Germain vs Barcelona
The French outfit have been rewarded (or cursed) for their exploits against Chelsea by a draw with in-form Barcelona in the last eight of the Champions League. Although the parisians dug deep and showed real quality against the Blues, they will be missing their talisman Zlatan Ibrahimovic due to the red card received at Stamford Bridge.
In addition, the Catalans are in fine form as they soundly beat Manchester City 3-1 on aggregate in the last 16. Plus, the electric form of Lionel Messi coupled with the absence of Zlatan means that the Spanish giants start as favourites in this mouth-watering tie.
Juventus vs AS Monaco
Granted, this one is a less entertaining prospect than the above two but with Juventus boasting a great attacking threat in Carlos Tevez, the tie promises to also be a tight affair.
Although Monaco qualified for the quarter finals by the skin of their teeth, they boast a solid defensive record at home and away in the Champions League and star midfielder Kondogbia has proved a revelation. Despite Paul Pogba set to miss both legs through a hamstring injury, the Italians will be hoping that they can out-class a valiant but under-whelming Monaco side in the quarter-finals.
Bayern Munich vs FC Porto
Those with a good memory will notice this quarter-final billing is a repeat of the 1987 European Cup final, which was won by the Portuguese side. How times have changed since... Although the Germans played out a dull 0-0 drawn in Ukraine against Shakhtar Donetsk, they duly found their shooting boots in the home leg as they thrashed their opponents 7-0.
The Bavarians are managed by Champions League "guru" Pep Guardiola and with their attacking trident of Arjen Robben, Mario Gotze and Thomas Muller all in fine form, the Portuguese outfit will not approach this tie with a lot of optimism.