Roberto Soldado's miserable time at White Hart Lane looks set to continue as he is the only doubt for Mauricio Pochettino's side as they host bottom of the table Leicester City.
The one-time Spain striker has struggled for goals again in North London, falling firmly behind Harry Kane in the pecking order.
However, he may have pinpointed the visit of Nigel Pearson's Foxes as a perfect chance to add to his singular goal in Premier League this season. However, his place - probably on the bench - is set to be taken by Emmanuel Adebayor as the league's basement club come to town.
After the dire display at Old Trafford last weekend, Pochettino may have considered making changes to freshen up his tired looking first XI, but such is the lack of confidence in the rest of the squad that it would be no surprise to see the same side play again.
Kyle Walker struggled against United but the bigger problem was the Head Coach's 4-2-3-1 formation, that was both ineffectual in attack and open in defence. Playing at home in North London, with the crowd behind them, Spurs will be expected to play on the front-foot and that will suit Pochettio and his men.
There are selection question marks over a couple of players. Walker will play as his understudy, DeAndre Yedlin, is still acclimatising since his January move from the MLS, while the other options like Vlad Chiriches and Eric Dier are centre backs by trade.
Ahead of Walker, Andros Townsend may find himself benched for Erik Lamela after his substitution just half an hour into the game last weekend. Nabil Bentaleb may get a rest for Benjamin Stambouli, while Nacer Chadli is struggling to regain his early season form and may make way for Moussa Dembele.
However, now the club is only competing on one front, and they are looking like one of the outsiders for a Top four finish, Pochettino may continue with the same players as he cuts loose those members who he doesn't rate.
Tottenham Hotspur - predicted Starting XI:
Lloris; Walker, Dier, Vertonghen, Rose; Mason, Bentaleb; Lamela, Dembele, Eriksen; Kane.