The Slovakian international could be banned for three matches if he is found guilty by The FA. It would be bad timing for Liverpool boss Brendan Rodgers, as club captain Steven Gerrard also faces a three match suspension for his red card in the same game.
The FA are free to use video evidence to examine the incident that took place between Skrtel and de Gea in stoppage time as referee Martin Atkinson has told The FA his view was obstructed.
Upon reviewing the evidence, the video panel decided that Skrtel would have been sent off had Atkinson seen the incident, even though Rodgers insisted after the game it was not as bad as it appeared on TV.
“My reading of it wasn’t that [a stamp],” the manager had said. “The ball has been played through and when it is slowed down it looks like he has caught him with intent. I didn’t see it like that.
"He is trying to get the ball. You see his foot up but that is a symbol when a player is just trying to get his toe on the ball because if he does that and the keeper brings him down it is probably a penalty. But when the keeper gets a studs it can hurt.”
Skrtel now has the opportunity to appeal the decision, but if he fails to convince The FA disciplinary committee of his innocence then he will be banned for Liverpool's next three games.
The Reds have Premier League matches against Arsenal and Newcastle on the horizon, with their FA cup replay against Blackburn Rovers set to be the third fixture under threat for Skrtel.
If the decision is upheld, or Liverpool decide against appealing, it will cap a disastrous derby for the Reds. With Gerrard also facing a ban for his stamp on Ander Herrera, Rodgers could be without two of his key players as Liverpool look to secure a top four spot.
The 2-1 defeat to Manchester United made that more challenging, although Rodgers is still confident.
What do you think Liverpool fans - are The FA right to have charged Skrtel for the incident?