Chelsea striker Loic Remy was ruled out of Sunday's west London derby against Queens Park Rangers after picking up a muscular injury in training the previous day.
The France international's absence paved way for Didier Drogba to lead the line for the Blues at Loftus Road after leaving Jose Mourinho with just one fully fit centre forward available for selection.
Remy's latest setback threatens to seriously derail Chelsea's Premier League title hopes with first-choice frontman Diego Costa also sidelined with an ongoing hamstring problem that has disrupted his debut campaign at Stamford Bridge.
It's not yet clear how serious the £90,000-a-week star's problem is, but with Costa expected to miss the next few games the Portuguese coach will be hoping that Remy returns to full fitness as quickly as possible.
Chelsea still have a wealth of attacking midfield options and are certainly not short on creative talent, but without a predatory marksman to finish off the chances engineered by the likes of Eden Hazard, Willian and Cesc Fabregas amongst others they'll find it more difficult to break their opponents down.
At 37 years of age Drogba is a fading force who is sadly way past his best, and Mourinho will be well aware the demands being placed on the veteran Ivorian if he's asked to play on his own at the focal point of the Blues attack for the remainder of the campaign.
It's an area of the squad that Roman Abramovich will surely prioritise strengthening over the summer, but for all the Russian billionaire's wealth he will be powerless to do anything to improve Chelsea's options between now and May.
Arsenal closed the gap at the top of the table to four points after recording a 1-0 victory over Burnley at Turf Moor on Saturday - their eighth consecutive win in the league - and will be breathing down the necks of the leaders hoping for a slip-up.
Chelsea fans: Are you worried about Jose Mourinho's lack of options up-front? Do you think it will come back to haunt you? Have your say below...