Manchester United boss Louis van Gaal has ruled out as many as four key players ahead of tomorrow's showdown with Premier League leaders Chelsea.
The Red Devils chief, who has led his side to six straight victories in England's elite division, has confirmed that he will be without the quartet of Michael Carrick, Marcos Rojo, Phil Jones and Daley Blind for the clash at Stamford Bridge.
With the Old Trafford outfit in excellent form, this will no doubt come as a major blow for the United boss, as he will now have to make big changes to his starting XI.
The trio of Carrick, Jones and Blind all started in United's thumping victory over Manchester City last weekend, while Rojo came on as a second half substitute.
The injuries certainly leave the Dutchman with a headache as he goes about selecting his back-line, with the Red Devils set to come up against the attacking class of Eden Hazard, Oscar and Co. tomorrow evening.
As well as the defensive injuries, the loss of Carrick will no doubt disrupt things in the United camp, with the England international having proved a key man for the club in recent weeks.
Arguably, the midfield ace has been one of the club's most consistent players throughout the course of the campaign, so Van Gaal will now have to turn to plan B as he goes in search of securing a positive result against Jose Mourinho's side.
After revealing that Luke Shaw is fit for the game, the former Southampton man will surely start at left-back at the Bridge. With Jonny Evans suspended, Chris Smalling may well partner Paddy McNair at the heart of the side's defence, with versatile Ecuadorian ace Antonio Valencia taking up the right-back role.
In midfield, United will no doubt stick with the likes of Marouane Fellaini and Ander Herrera, with Argentine ace Angel di Maria hoping for a recall. Perhaps, then, Van Gaal will hand either of Fellaini or Herrera a more reserved role in the absence of Carrick.
One thing's for sure, ahead of such a key game, these injury setbacks certainly aren't ideal for United as they go about securing Champions League football for next season.
Manchester United fans: Who do you expect to start tomorrow after this news? Have your say in the comments section below!