The Spanish midfielder came to prominence as an Arsenal player before eventually forcing his way out of the club to join Barcelona. Having come through La Masia before leaving for north London, Fabregas felt compelled to return to his boyhood club.
But the move did not work out as well as hoped and he was forced out of the Nou Camp last summer. Arsenal were offered the chance to sign Fabregas, but Wenger turned down the chance.
As a result, and at much despair to Arsenal fans, Jose Mourinho managed to sign him for Chelsea and he has since gone on to become a key figure in their fight for the Premier League title.
On the eve of his return to the Emirates, Wenger has called on Arsenal fans to respect their former captain, insisting Fabregas has earned the right not to be booed by fans that once adored him.
He told reporters: "I want every player to be respected, and Cesc Fabregas, when he comes to the Emirates on Sunday, to be respected like he deserves."
Indeed, it seems that Fabregas was expecting Arsenal to make a bid to re-sign him, but found that there was no longer a place for him at London Colney.
Mesut Ozil had been signed in the previous summer transfer window and Wenger's transfer priorities lied elsewhere.
Asked if he regretted not taking up the option to bring Fabregas back, Wenger dodged the question and instead pointed towards the playmaker's original decision to leave Arsenal as his biggest source of disappointment.
He said: "The regret I have is that he wanted to leave here.
"This club and myself had a very positive influence on Cesc’s life, so I would be a bit uncomfortable to have to justify today why he is not here. I believe I would rather it was the other way around."
We have relevant Arsenal news which you might be interested in. Does the name Bacary Sagna mean anything to you? Well, it should do.
If you remember, Mr Sagna left Arsenal after refusing the extend his contract, signing for Premier League rivals Manchester City.
Then he disappeared, only to re-emerge when Pablo Zabaleta was on holiday or in the treatment room.
But despite his lack of game time for the Citizens, Sagna has admitted that he has no regrets over leaving Arsenal and would do it all over again if he was thrown back in time and forced to remake his decision. Burn.
More other news
People are starting to question whether Thierry Henry has what it takes to become a top pundit like Gary Neville. The former Arsenal hero has been working for Sky Sports for several months but has not really said anything of interest as of yet. That changed last night.
Henry lampooned Javier Hernandez for, umm, celebrating a last minute goal to send Real Madrid into the semi-final of the Champions League. Yeah, Thierry. You tell him.
Read those crazy quotes right HERE