The pressure will all be on Real Madrid if Barcelona have beaten Espanyol by the time Real kick off against Celta Vigo at Balaidos. That said, Los Blancos need to be looking to win every match from this point to begin to reel in Barca from their perch at the top of the table.
Just one slip up from the Catalans will let their arch-rivals back into the title race, so there's still all to play for.
Let's take a look at three things that could shape the outcome of this one...
If Carlo Ancelotti can mastermind a win at Balaidos, then he'll be some way to taking the title race right to the wire. But it's a ground where they've struggled recently losing two of the last three games at the venue.
Eduardo Berizzo's team are in reasonable form and gave Barcelona a super game until Jeremy Mathieu's late decided.
They've already disposed of Atletico Madrid at home, and the last game at Balaidos saw them give Rayo Vallecano a 6-1 thumping. Write them off at your peril.
Injury concerns for Real
Carlo Ancelotti managed to deal with his injury worries remarkably well in the second leg of Real's Champions League quarter-final against Atletico Madrid.
However, with Chicharito now struggling to be fit for the weekend after somehow injuring himself whilst scoring the winning goals, Real find themselves lighter still in an attacking sense.
The donkey work will fall on Cristiano Ronaldo's shoulders which is unlikely to sit well with the Portuguese. He is a taker not a maker of goals.
Luka Modric's injury is the worst of the few that have manifested themselves over the last week or so, and it's unlikely that he will be back until next season.
Ancelotti will be thanking his lucky stars that James Rodriguez and Sergio Ramos recovered when they did.
Real still aren't as cohesive a unit as they were a few weeks ago, and this provides Celta with an opportunity to expose any weaknesses.
No sooner had he been cast back on the scrapheap once James Rodriguez returned to fitness, than he was thrust back into the limelight because of Modric's injury.
Isco has been one of Real's players of the season and has finally had long enough in the side to show the full extent of his skills.
Energetic, positive and dynamic, the youngster could end up being the match-winner for Los Blancos if he's allowed to dictate the pace of the game and patter of play.