Liverpool showed several clear signs of an FA Cup semi-final defeat hangover against West Bromwich Albion at the weekend in a bore draw whilst Hull City enjoyed the best of a 2-0 away victory against Crystal Palace.
David Meyler returns from suspension after a two-game ban following his red card against Swansea City three weeks ago, however Steve Bruce is likely to play the eleven that won at Selhurst Park on Saturday.
Curtis Davies remains on the sidelines with a thigh problem along with Andrew Robertson who is currently nursing an ankle injury.
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Mo Diame's never-ending injury saga continues to the annoyance of those involved at Hull City as a knee issue has further ruled out the Senegalese international.
Similar to Hull's talismanic central midfielder, Daniel Sturridge is yet again set to miss out through a hip complaint.
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Lucas Leiva is out with a thigh issue, the fitness of Alberto Moreno is set to be assessed by the Anfield medical staff, whilst Dejan Lovren is set to deputise for the absent Mamadou Sakho.
Prior to their weekend triumph, the Tigers' last victory came in mid-February against fellow relegation rivals Queens Park Rangers, picking up points against Leicester and Sunderland along the way.
Spirit is certainly something that appears to be lacking at the KC Stadium and manager, Steve Bruce will be hoping that their victory a few days ago can boost the players' belief levels.
Liverpool aren't enjoying football at the moment. An FA Cup semi-final defeat to Aston Villa last week was a devastating blow that knocked the wind out of Brendan Rodgers' side. That clearly showed at the weekend when a lacklustre Reds side failed to score at the Hawthorns, and the unavailability of Daniel Sturridge will make their goalscoring issues more problematic.
Hull know that one more win could pull them away from the relegation zone, and with that in mind ahead of Tuesday night's clash, they may play with a certain urgency to claim all three points.
Leicester may be out of the relegation zone, but Nigel Pearson is in hot pursuit of his former club. The Foxes face league leaders Chelsea on Wednesday and if Hull fail to win, there will be a clear opportunity for them to zoom clear of the drop zone.
With that in mind, Steve Bruce will be instructing his players to create some distance from their rivals, plus piling the pressure on Newcastle United who are being dragged into the mix at the last minute.
Liverpool will want to win this game just as much, however, so as to keep their Europa League qualification hopes alive and breathing. The Reds currently accommodate that well regarded fifth place position and a victory in East Yorkshire on Tuesday night will steer them three points clear of Tottenham Hotspur.
I really fancy this game to be a draw. Both teams are desperate for their own success, but I think with the home advantage, Hull are more likely to capitalise on the opportunity to give themselves with some breathing space.