Make sure you're watching the TV at 5:30pm on Saturday night because Steven Gerrard is set for an emotional Anfield send-off in Liverpool's final home game of the season against Crystal Palace.
However, prior to that blockbuster tie, there are a whole host of relegation dog fight fixtures at 3:00pm that could throw yet another spanner in the works at the foot of the table.
So, here are our predictions to how the day will pan out.
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Southampton 2 - 0 Aston Villa
It's relegation fighting sides 2, Southampton 0. Over the past fortnight, Ronald Koeman's side have been beaten twice by teams at the bottom of the table who are scrapping for their lives. Last week it was Leicester who demolished the Saints after Sunderland claimed a fortunate three points over them.
They need to bounce back here against Villa otherwise that will be a trio of defeats against relegation threatened clubs. Anything less than a win isn't good enough to earn Southampton a place in next year's Europa League so there will be a desperate game on show as a win will secure Aston Villa's Premier League status.
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Burnley 1 - 1 Stoke City
Despite their hard-fought victory against Hull City last week, Burnley were relegated from the Premier League, which is a shame because they've always given the big teams a real contest this season.
Sean Dyche will be telling his men that they should be playing for pride. Now the pressure is off, I fancy them to snatch a couple of points from Stoke City, who are targeting their highest ever Premier League finish.
Queens Park Rangers 2 - 1 Newcastle United
QPR, like Burnley, have been ejected from the league, and have also got nothing to play for but pride. Their degrading 6-0 thrashing against Manchester City last week was a horrible way to exit the top flight and they will be desperate to bring Newcastle down with them.
One way they can do that is by beating them on Saturday at Loftus Road. It's their final home game of the season, so they'll be hoping to give their fans something to cheer about for once in a while.
Newcastle on the other hand got their first point since February last week. They could use that as a confidence boost in the same way.
Sunderland 0 - 2 Leicester City
I'm not quite sure if we've been watching Leicester or Barcelona over the past seven weeks. It's now six wins from those games which is the same amount of games they had won before this streak began. What an unbelievable statistic!
Sunderland, too, have started to collect several points, and they'll be looking for a treble of victories ahead of the Foxes' visit.
I can't help but notice the sheer luck that Dick Advocaat's side have been gifted with over the past fortnight. Surely they won't get away with it again, will they?
Tottenham Hotspur 1 - 1 Hull City
It really is last chance saloon for Hull City after last week's shock result at home to Burnley. I don't think many people saw that one coming.
Although they can't be relegated this weekend, defeat really would spell disaster for the Tigers ahead of a dooming home tie against Manchester United next Sunday.
Spurs will be just as desperate to win, however. They know that anything less than a win will virtually destroy their hopes of making the Europa League next season.
West Ham United 0 - 1 Everton
West Ham have crumbled in the second half of the season since their talismanic forward, Andy Carroll, picked up a season-long injury. Everton, too, haven't enjoyed the best of campaigns, but have started to come good of late despite being beaten at home to Sunderland.
I'm fairly confident that the Toffees can pull through with a win here.
Liverpool 2 - 0 Crystal Palace
It's time to say goodbye to Anfield, Steven Gerrard. It's been an amazing spell at Liverpool for him, but everything has to come to an end. It will be emotional but Gerrard is a strong character and should be able to hold the waterworks.
It's a great time to get revenge as well. Crystal Palace were the side who virtually downed Liverpool's title dream last year, and I expect Gerrard should get payback.