Higuain, 27, admitted it was a tough choice to name the best player in the world outside of Argentina - it's safe to assume he would have selected compatriot Lionel Messi as the greatest footballer on the planet - but he opted for Real Madrid's Ramos over the three-time Ballon d'Or winner Ronaldo.
“It’s hard [to pick]. There are many,” Higuain told reporters at the Copa America, according to the London Evening Standard. “If I have to pick it would be one I became very good friends with: Sergio Ramos.”
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There's a small possibility that Higuain and Ramos will be reunited at Old Trafford next season.
Manchester United are reportedly keen on Higuain, who has a €100 million release clause, with Radamel Falcao having left the club earlier this summer.
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Napoli, however, are reluctant to sell the South American striker who has scored 53 goals in 102 appearances since arriving in Naples from Madrid two years ago.
Sergio Ramos 'wants' to leave Real Madrid
Rumours involving Ramos and a shock move to Manchester United, meanwhile, intensified on Sunday afternoon.
Spanish newspaper AS understand the World Cup winner has made a decision to leave the Bernabeu this summer, angered by Real Madrid's failure to deny reports linking him with an unlikely move to rivals Barcelona.
United have asked for Ramos in exchange for their wantaway goalkeeper David de Gea, according to the Guardian, but the odds of the Spain international ending up at Old Trafford appear to be slim.
Ramos wants an improved contract from his current employers - and it seems Manchester United are being used in the same way Dani Alves used the Red Devils and Paris Saint-Germain before signing a new deal with Barcelona earlier this month.
United's interest in Ramos is no surprise
That United are interested in signing Ramos should come as no real surprise: the 29-year-old is one of the world's best centre-backs and a born winner.
Louis van Gaal is reportedly keen on both Borussia Dortmund captain Mats Hummels and Valencia's Nicolas Otamendi, but the veteran Dutch coach is likely to prioritise Ramos if the Spaniard is genuinely interested in quitting Real Madrid this summer.
However, few would agree with Higuain's assessment that Ramos is a better player than Ronaldo, who is unquestionably one of the greatest footballers of all time.
It simply goes to show that Higuain was closer to the defender than Ronaldo during his spell at the Bernabeu.
Will Gonzalo Higuain or Sergio Ramos sign for Manchester United this summer? Have your say by leaving a comment in the box below!