Warrington are the cup kings of late, winning three of the last six, but history will be made with a win for Leigh, as it will be the first time a non-Super League side has contested a Challenge Cup semi-final since Hull KR in 2006.
The prospect of facing a Super League side is not a daunting one for the Centurions who, in the previous two rounds of the cup, have defeated Salford 22-18 and Wakefield 30-36.
For the Wolves, the win is a necessity. They currently sit in 7th position in the Super League table, but there is a real possibility that they could find themselves out of the playoff positions within the fortnight and, even more worryingly for their fans, battling against relegation in the 2nd tier Super 8s.
And there is no doubt that, should Warrington have their worst placed season since 2010, and fail to make the playoffs, they will be facing off against Leigh in the battle for Super League status.
The Centurions currently sit top of the table in the Championship, and have lost only ONE game all season.
Game of the weekend
With only six games remaining, it is near mathematically impossible for them to not be competing for a Super League space, with 10 points the difference between them and fifth place.
The form of the Leigh side must be taken with a pinch of salt, as they are winning all the games that they ought to be winning.
The form of the Warrington side, however, is of a different story. They have lost to both Hull KR and Huddersfield in their previous two games; both games are those which the Warrington side should be expecting to win.
The game serves to be the spectacle of the weekend.
Both sides have a philosophy to rugby that is built on their confidence and ability to score points. If, in that process, there is a necessity to concede a few tries per game, then so be it. When two teams of that nature face off against one another, it is sure to be full of points.
Warrington needs the win more
Add to all of this the fact that it is a knock-out game, for a place in the semi-finals of the Challenge Cup, and both teams will be forced to go for the win.
It is not really a win that Leigh need, in the sense that Warrington do; the former have already beaten two Super League teams and their main focus of the season will be promotion above all else.
This means that they can relax, and play the game with enjoyment.
Warrington could not be more opposite, and if they lose, they may also be forfeiting their final chance at silverware this season.
That would mean they have not won anything since the 2012 season. Were that to happen, the questions being raised by fans may be reciprocated by the board of directors.