Scott Quigg defends his 122Ib belt on the same night as rival Carl Frampton, who makes his U.S debut tonight.
Both champions will be looking to win and make statements, with the hope of a domestic clash between the two in the near future.
26-year-old Quigg faces the hard hitting Spaniard Kiko Martinez. The challenger, known as 'La Sensacion', is the former IBF ruler, and is a well known traveller, having won his strap in the U.S and defended it successfully in Japan.
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Martinez lost his title to Frampton last year but is looking to become a two-time world champion tonight. The Englishman Quigg is facing a high-risk, low reward bout at the Manchester Arena.
The champion will inevitably have his performance compared to Frampton's, who has beaten Martinez twice, once by KO (2013) and most recently last year on points. The Bury fighter would need a early stoppage in order to better the Jackal's victories over Martinez.
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Frampton's U.S debut
Frampton meanwhile is looking to shine in the States, as he takes on Alejandro Gonzalez Jr in Texas. The 28-year-old IBF champion has recently signed with Al Haymon and is looking to make a statement in a bid to become a global star.
Last time out the Northern Irishman dominated Chris Avalos, making his first title defence in February. The former Commonwealth champion has looked sensational so far in his career and is looking to emulate the success of his co-manager Barry McGuigan.
As both domestic rivals Quigg and Frampton are fighting this weekend, the fight fan dream is that they get through their defences and continue the verbals towards each other and down the line a domestic mega-fight will be finalised.
In April, Quiggs promoter Eddie Hearn offered his would-be opponent a cheque for £1.5million and a 60/40 split to the winner. This offer appeared to insult the IBF Super Bantamweight champion, and Mcguigan, who believe more money can be made from this bout and that it would sell better in Belfast rather than Manchester.
The IBF ruler has also disregarded Quiggs reign as a W.B.A 'regular' holder, calling him a "paper champion" as W.B.A 'super' champ Guillermo Rigondeaux is known as the board's official belt holder.
After Saturday UK fans may well have missed out on the chance of seeing these two in the ring together. If Quigg or Frampton lose then they slip back down into contender status and a potential domestic clash will have lost all its appeal.
They both need each other to secure their status and make the most money in this division, the WBA champion will have his work cut out for him at the Manchester Arena and the IBF king will need to impress. Let's just hope both men win and continue their path towards one another.
Fight fans, is there a juicier domestic showdown available at the moment? Let us know what you think in the comments box below.