One a die hard Red Devils fan, the other has Liverpool in his blood. Both are legends at their respective clubs.
Neville is a hero to the Old Trafford faithful, while Carragher's name was chanted passionately from the Kop.
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However since they began working together at Sky Sports their relationship has changed. You could even say that the two have began to like each other.
They are known for their hilarious banter on Monday Night Football and the pair have been at it again, this time while playing FIFA 16.
A BETA version of the latest instalment of the EA series was handed to the former players turned pundits, with a whole new game mode 'FIFA Ultimate Team Draft'.
Neville and Carragher are tasked with picking an ultimate team together from a selection of players that the game throws up per position.
It starts well with them agreeing that Messi should be the captain, however the cracks begin to show as Neville takes control of picking the back four.
First ignoring Carragher's claim that Marcelo should be the starting right-back, then leaving out his former Liverpool team-mate.
It becomes too much for the Anfield legend to bare when Neville picks Shinji Kagawa in the midfield ahead of Kevin de Bruyne, and threatens to leave out Steven Gerrard.
Carragher snatches the controller from the former right-back and asserts his dominance on the situation by selecting the former Liverpool captain.
Having picked a complete team they take played a match, on the same team, which had some equally hilarious moments.