Ashton Agar is one of three uncapped one-day international players named in Australia's limited-overs squad for the tour of England and Ireland.
New one-day captain Steve Smith will lead a much-overhauled side from the one that triumphantly won the World Cup on home soil earlier this year, with the injured Aaron Finch and suspended James Faulkner among the notable absentees.
Six new faces come into the ODI squad, with slow left-armer Agar, batsman Joe Burns and all-rounder Marcus Stoinis set to earn their first caps in the 50-over format.
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Agar and Burns have each played two Tests, the former making his mark in the 2013 Ashes series with a wonderful 98 from 101 balls at number 11 on debut at Trent Bridge.
He was dropped after the second Test at Lord's following a wicketless return although he is back in the international reckoning as the only specialist spinner, having taken five for 39 for Australia A against India A earlier this week, with leg-spinner Cameron Boyce in the Twenty20 squad only.
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Burns, who struck 154 off 131 balls against the same opposition in a different match, could partner David Warner at the top of the order, with regular opener and Australia's Twenty20 international captain Finch missing due to a fractured foot.
Chairman of the national selection panel Rod Marsh said: "The squad we have selected has a few fresh faces in it as well as some experienced players that will provide us with the right balance.
"Ashton has performed very well with the ball since his return from shoulder surgery including taking five wickets in the recent Australia A game in India. He has played in these conditions over here before and the NSP believes he has a very bright future."
"Joe has impressed us immensely over in India with Australia A. He is a very capable young batsman who has experience opening, and we think he will grab his opportunity with the white ball during this series."
Shane Watson retains his place although Faulkner misses out after being convicted of drink-driving in England last month, with his place going to Stoinis, uncapped at international level.
"Marcus has performed very well in India during the four-day series and we have always liked that option of the extra all-rounder in our side, so with James Faulkner's unavailability this is a great opportunity for Marcus," added Marsh.
Paceman Mitchell Johnson and Josh Hazlewood will be rested, with James Pattinson and Nathan Coulter-Nile named as their replacements, while wicketkeeper Matthew Wade comes back into the squad after the ODI retirement of Brad Haddin.
Smith, captaining the side for the first time following the retirement of Michael Clarke, will lead Australia in a one-off ODI against Ireland in Belfast on August 27 and the only T20 match against England four days later in Cardiff.
The tourists will then play five ODIs, between September 3-13, against Eoin Morgan's side.
Australia squad: S Smith, A Agar, G Bailey, Cameron Boyce (T20 only), J Burns, N Coulter-Nile, P Cummins , M Marsh, G Maxwell, J Pattinson, M, Starc, M Stoinis, M Wade, S Watson, D Warner.