The Barclays Premier League giants will face each other three times in a week next month, with a top-flight match sandwiched between the two legs.
Manchester United will face Roma - who they have played in the competition already this season and knocked out a year ago - with the second leg at Old Trafford.
Copyright (c) PA Sport 2008, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms