The line-up looks to include more first team players than the previous more experimental side that faced the French last week on home soil, with 14 changes being made to the starting line-up, leaving winger Jonny May as the only player to keep his place.
Joe Launchbury will return from injury to play his first international in 12 months, as Saracens hooker Jamie George looks to come off the bench to get his first cap for England.
Stuart Lancaster will only look to take two hookers and with Luke Cowan-Dickie failing to control England's line-out in the second half last week, enduring a miserable debut, George may fancy his chances of potentially sneaking a spot in the squad ahead of the dependable Rob Webber.
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Centres Luther Burrell and Billy Twelvetrees will need to impress with new boys Sam Burgess and Henry Slade having enjoyed impressive debuts at Twickenham.
Sale Sharks' troublemaker Danny Cipriani, who has been used sparingly since being called up to Lancaster at the beginning of the year, will be hoping to come off the bench earlier than last week in Paris this Saturday.
The fly-half has been in tantalising form all season for Sale Sharks but has seen chances hard to come by with the emergence of George Ford and the solid, yet uninspiring Owen Farrell.
A regular front row of Joe Marler, Tom Youngs and Dan Cole will surely sure up the scrum after England toils in last week's match.
The return of Bath centre Jonathan Joseph, who gained many an admirer with his lightning speed and skilful play during this year's Six Nations, will surely spark up an England back line that looked a little tired and lacklustre in the second-half against France.
M Brown (Harlequins); J Nowell (Exeter), J Joseph (Bath), L Burrell (Northampton), J May (Gloucester); G Ford (Bath), B Youngs (Leicester); J Marler (Harlequins), T Youngs (Leicester), D Cole (Leicester); J Launchbury (Wasps), C Lawes (Northampton); J Haskell (Wasps), Chris Robshaw (capt, Harlequins), Billy Vunipola (Saracens).