The Stamford Bridge club have made a stuttering start to the season and find themselves five points behind Manchester City already.
The Blues are still looking for their first win of the season and could be eight points behind City on Monday night, should results go against them.
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Chelsea conceded an eight point lead themselves last season, but bounced back to win the title, before losing 3-0 at the Hawthorns.
But Mourinho is not concerned by the prospects of Chelsea losing again, and believes his side can catch the fast starters even if they drop points today.
As relayed by ESPN, he said: "We can [afford to lose]," "Eight points in England is 80 points in other leagues, because in other leagues, eight points is an eternity.
"It's very difficult in other leagues for teams to lose points. In England, teams lose points."
THE BLUES NEED TO START
Chelsea travel to the Black Country today to face Tony Pulis, who boasts an impressive record against Mourinho, having won two of the last three meetings between the two managers.
Following a draw at home to Swansea and a thumping away at City, the pressure is building on the defending champions to get their season rolling.
The introductions of Pedro and Baba Rahman have bought some much needed new blood to the Chelsea squad and there is a chance both players could make their debuts in the West Midlands.
Despite Mourinho's assertion they can afford to lose, the Portuguese manager will be keen to see his side take all three points today and ensure the pressure does not grow on himself and his side.