It was the first time Terry had ever been hauled off by Mourinho, and lead to many people questioning whether it was signalling the end of the 34-year-old's time at the centre of Chelsea's defence.
The former England skipper, along with Gary Cahill, were torn to pieces by Sergio Aguero in the opening 45 minutes, and Mourinho opted for a faster option in the heart of defence by bringing on Kurt Zouma.
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A lot of defenders have experienced a torrid time against Aguero, and Mourinho has come out to rubbish claims his time was coming to an end, with Terry expected retain his place in the starting line-up for the trip to West Bromwich Albion.
However it is clear to see that a changing of the guard will have to happen in the Chelsea back-line at some point in the near future. Terry can not go on forever and the club have already began to chase long-term replacements.
According to the Mail, Chelsea have enquired about the availability of Real Madrid centre-back Raphael Varane, with Mourinho a long term admirer of the France international.
However Madrid are unlikely to want to sell the 22-year-old, who has already made 117 appearances for Los Blancos since joining from Lens in 2011.
Having had three bids rejected for John Stones, Chelsea are reportedly preparing a fourth offer in the region of £34 million for the 21-year-old, with further reports claiming the former Barnsely man is now prepared to force a move away from Goodison Park.
These two players could potentially be long term stalwarts in the Chelsea defence, however it is too early to write Terry off.
He has come back from adversity on a number of times in his career, and having enjoyed arguably his best season for many years in the last campaign, the Blues captain is sure to bounce back.