With both managers already under scrutiny from the media, Louis van Gaal and Brendan Rodgers will be eyeing their clash this coming weekend as a must win for the sake of their respective sides' title credentials, and maybe even their jobs.
Both Manchester United and Liverpool got off to the season with unbeaten starts, winning their opening two games and drawing their third, but both suffered shock home losses in Gameweek 4, with United losing 2-1 to Swansea and Liverpool beaten 3-0 by West Ham.
Liverpool's defeat was particularly shocking given that their defence had been largely on the receiving end of praise, but against a Hammers side who had already beaten Arsenal away from home they looked completely out of sorts.
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United, on the other hand, were overturned in what was arguably their first true test of the season against the Swans, who had enjoyed a solid start to the season under the tutelage of Gary Monk. The Red Devils started the game stronger and were largely dominant throughout but were unable to find an end product, whereas Monk's men were clinical and destructive.
Football is a fickle sport, though, emphasised by the fact that both sets of Manchester United and Liverpool fans will have been ecstatic by their starts, but will now be asking questions of their players to react and get back to winning ways.
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And such is the fickle manner of football that, alas, both Rodgers and Van Gaal's jobs are under threat, with the former at 6/1 to be the next manager to lose his job, while his Dutch counterpart boasts safer odds of 50/1.
Both managers will be under immense pressure going into what is the biggest rivalry in English football knowing that a loss could not only see them fall eight points adrift of the top, but also heighten their chances of being axed.
It's very early in the season, though, and it's highly unlikely that clubs of Liverpool's and United's stature would be so rash in axing managers that they have stated belief in so early on, but a second loss on the bounce for either of these side's won't do the team's confidence any good, which could ultimately bode negatively for one of these experienced managers.