Andrea Pirlo put Milan ahead after 18 minutes at the San Siro, Julio Cruz replied in the 36th minute but Esteban Cambiasso then sealed the 2-1 win just after the hour to leave Inter with a healthy advantage over nearest challengers Roma.
Juventus complete the top three after their 2-0 success over Siena with goals from Hasan Salihamidzic and David Trezeguet.
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