A youthful Gunners side took the lead in the 11th minute through Eduardo da Silva, but Sevilla hit back to claim a deserved win and join Arsenal in the last 16.
Seydou Keita levelled the scores up soon after Eduardo´s strike, before further goals from Luis Fabiano and former Tottenham striker Frederic Kanoute - from the penalty spot - wrapped up the win for the hosts.
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