The infamous injury backlash stereotypical of the international break appears to have taken its toll once again on one of the Premier League's elite, with Manchester City all-but-set to take on Crystal Palace without some of their stars.
Central midfielder Fabian Delph pulled up with what seemed to be a hamstring injury just ten seconds into England's affair with Switzerland on Tuesday which, if confirmed to be yet another pull, could rule out the City man for a month.
Alongside Delph's injury comes right-back Bacary Sagna. The 32-year-old appeared to have taken a knock to his ankle before being substituted ten minutes before half-time in France's bout with Serbia.
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The France international had to apply ice to the injury in what City will hope is only a minor knock and little more than a safety precaution.
Any long-term injury for Sagna, though, will come as a big blow for Manuel Pellegrini given that Argentine Pablo Zabaleta is currently out with a knee injury for the foreseeable future.
Should any substantial injury be confirmed, Pellegrini will have a tough decision to make in terms of who can deputise at right-back, with left-back Gael Clichy or even Eliaquim Mangala arguably their best options.
Mangala was often played at full-back for former club Porto and would prove a sufficient replacement, though this would disrupt the strong partnership that he and Vincent Kompany have forged so far this season in the heart of City's defence.
Finding cover for Fabian Delph, on the other hand, shouldn't be too much of an issue given that he doesn't hold a place in Pellegrini's starting line up, with Yaya Toure and Fernandinho distinct favourites in the centre of the back.
Despite this, Pellegrini will be still made to rue yet another injury to his summer signing, whose luck doesn't seem to have eased since his heavily criticised move to Manchester from Aston Villa.